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KMID : 0861020060210040123
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Korea Journal of Herbology
2006 Volume.21 No. 4 p.123 ~ p.131
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Effects of Ginseng Radix plus Crataegi Fructus on the injury of brain tissue in the mice with Alzheimer’s disease induced by {beta} amyloid peptide({beta}A).)
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Han Sin-Hee
Kil Ki-Jung
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Abstract
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Objectives : This research was investigated the effect of the Ginseng Radix plus Crataegi Fructus on the injury of brain tissue in the mice with Alzheimer’s disease induced by (beta}A.
Methods : Observed a change of the injury of brain tissue and reduced the infarction area of hippocampus in the mice with Alzheimer’s disease induced by {beta}A.
Results : 1. The Gin-CF extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer’s disease induced by {beta}A. 2. The Gin-CF extract reduced the Tau protein, GFAP protein, and presenilin1/presenilin2 protein (immunohistochemistry) of hippocampus in the mice with Alzheimer’s disease induced by {beta}A.
Conclusion : These results suggest that the Ginseng Radix plus Crataegi Fructus extract may be effective for the prevention and treatment of Alzheimer’s disease. Investigation into the clinical use of the Ginseng Radix plus Crataegi Fructus extract for Alzheimer’s disease is suggested for future research.
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KEYWORD
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Ginseng Radix, Crataegi Fructus, Alzheimer’s disease
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